Bosses are a unique enemy class outfitted with superior weapons, high health, rechargeable shields, special abilities, and other traits. They are far stronger than regular units as they will use varying strategies to deal damage and avoid taking it. More often than not, they require team coordination to defeat.
These Bosses are found on Assassination missions. Each boss has a set of lines to "taunt" the Tenno sent to kill them. They drop mods and resources upon death. Depending on which Boss the player is fighting, Blueprints of Warframes parts and special Weapons parts will often be rewarded upon mission completion.
- Main article: Captain Vor
Captain (formerly Admiral) Vor is the first boss in WARFRAME that players will encounter and is one of the few figures in the game that understands ancient Orokin technology, capable of utilizing it and merging it with Grineer technology to create offensive weapons such as his trademark Seer pistol and his armor, which is powered by a Void Key and grants him a powerful ranged beam attack. Captain Vor can be encountered in three locations currently, making him the most recurring boss beside assassins. First appearing on Mercury and thus being the first boss that players must fight, he then appears again, somehow fully alive, on Phobos as a dual boss battle alongside Lieutenant Lech Kril, then appearing later yet again as a Corrupted version of himself within the Void.
- Main article: Councilor Vay Hek
Councilor Vay Hek is the final boss of Earth. He is the most political Grineer figure players meet, marked by the Lotus for extermination for upsetting the balance in the system by killing several political opponents. Vay Hek is also heavily modified with Grineer alterations, with little flesh left noticeable while he rides in his giant Terra Frame.
- Main article: General Sargas Ruk
General Sargas Ruk is the final boss of the Saturn system. The head of one of the Grineer Artifact extraction projects, Sargas Ruk was targeted by the Lotus for annexing Tenno-controlled dig sites. Ruk enjoys Grineer augmentation, even going as far as replacing the lower part of his arm with a flamethrower and replacing his normal vision with a single augmentation in the center of his helmet.
- Main article: Kela De Thaym
Kela De Thaym is the boss of Sedna. According to the Lotus, all female Grineer undergo combat training. However, in Kela's case, she was the most battle hungry and extended her own term another decade before returning to the Grineer Court. She has influence within the Court, which is the main reason why the Lotus has targeted her for assassination as her death would cause a power vacuum in the system. The only female Grineer boss players encounter, she was specifically built for combat personally by the Sisters, with most of her body replaced with augmentations.
- Main article: Lieutenant Lech Kril
Lieutenant Lech Kril is the boss of Ceres, and a dual boss on Phobos alongside Captain Vor. A revered war hero clad in impenetrable armor and armed with his signature hammer and Cold/ Heat abilities, Lech Kril is a formidable adversary for anyone who opposes him.
- Main article: Tyl Regor
Tyl Regor is the final boss of the Uranus system and the head researcher focusing on Grineer gene repair in an attempt to reverse the negative effects from excessive cloning. He was targeted by the Lotus in order to slow down this progress, ensuring that the Grineer do not become more powerful.
- Main article: Alad V
Alad V was the head of Grineer Relations and reported directly to the Board of Directors. In spite of his position, Alad V showed a particular contempt towards the Grineer (whom he refers to as 'dogs') and to a lesser extent, the Tenno. He is the most decorated Corpus boss in terms of his involvements with many Events. He eventually became obsessed with the promise of biological research on the Infested, with the hopes of creating very powerful bio-weaponry, going as far as using Technocyte on his own armor and sacrificing prototypes from his Zanuka Project.
- Main article: Ambulas
Ambulas is the boss of the Pluto system, representing a black MOA but with more dangerous attributes. Besides having high health, alloy armor, and a proto shield, it has a high damage machine gun and two abilities that mirror Fire Blast and Pull, making it a dangerous opponent when also surrounded by other Corpus units. It was targeted for assassination by the Lotus to prevent further Ambulas models to be manufactured, although it is unknown if more models exist.
- Main article: Hyena Pack
The Hyena Pack are the final bosses of the Neptune system, made up by 4 unique and deadly variants of the Hyena proxy. They work in packs of up to four with each of them possessing a unique set of abilities. Each Hyena possesses a plasma repeater, and they are far more agile than any other enemy(other than the Grineer Manic) in the game, including Zanuka and Zanuka Hunter. Alongside their agility, they can also jump on to and cling to walls, though they cannot wallrun. Lotus has marked them for assassination for obvious reasons, as they are a very dangerous proxy group and destroying the models may slow down further production.
- Main article: Jackal
Jackal is the final boss of the Venus system, and represents the first Corpus boss that players encounter. Although a more bulky and old model compared to more recent Corpus robotics, the Jackal possesses invulnerable shields, a giant shockwave ability to knock players down, and one of the most powerful corpus weapons, the Plasma Grenade Cluster. Dissected models of the Jackal can be found in some Grineer tilesets, either showing that the Grineer have interest in utilizing Corpus technology, or that they have simply purchased merchandise.
- Main article: Raptor
The Raptor is a Corpus Boss found in the Europa system, and the only flying Corpus boss in the game. It has very high stats and heavy hitting weapons, including launching high damage missiles that seek players, deploying mines and firing explosive laser bolts, making fighting in the open a difficult task. It was marked for assassination for being a high threat risk, as more models of this proxy could result in dangerous repercussions.
- Main article: The Sergeant
The Sergeant, formerly known as Sgt. Nef Anyo before Update 16.4, is the final boss of Mars system. He is in charge of the Corpus solar rail systems, using them to obtain Cryopods with dormant Warframes for resale to rogue scientists and splinter groups. When confronted by the player during the mission, he has a very aggressive tone towards the Tenno and warns the player that they are making a fatal mistake by attempting his assassination. He also may demand information regarding Orokin secrets, or make fun of the player's Warframe or teammates.
- Main article: Mutalist Alad V
Controlled by the Infested and corrupted with its power, Mutalist Alad V is the boss of Eris introduced in Update 15.5. To fight him, players need to craft the Mutalist Alad V Assassinate Key with the blueprint awarded from completing the Patient Zero quest.
- Main article: Lephantis
Lephantis (previously known as J-2000 Golem) is a massive Infested boss introduced in Update 10. It was originally going to replace the now retired J3-Golem boss but was moved to the Orokin Derelict tileset instead. To fight Lephantis, the player has to craft a Derelict Assassination key, which requires five Lephantis Nav Coordinates. These special Nav Coordinates are only obtainable though Derelict missions.
- Main article: Phorid
Phorid is an Infested boss, found when an invasion takes over the Assassination mission of a planet. After defeating it and finishing the mission, you receive a Nyx Helmet, Chassis, or Systems blueprint. Upon death, Phorid has a chance of dropping rare resources of the planet he appears on.
- Main article: Juggernaut Behemoth
The Juggernaut Behemoth is a massive quadruped Infested creature, armed with formidable ranged attacks and deadly close-quarters combat abilities, which combined with its heavy armor makes it an intimidating opponent. Initially introduced in the Black Seed Scourge Tactical Alert, it can now be found in the last mission of The Jordas Precept, as well as the first portion of the Jordas Golem assassination mission.
- Main article: Jordas Golem
The Jordas Golem, also known as J3-Golem, is the Infested Boss of Eris. An amalgamation of Infested flesh merged with Corpus ship technology, the massive Jordas Golem uses powerful weapons combined with its formidable armor to combat enemies in deep space. The Jordas Golem is found in its own Assassination node on Eris after a player has completed the Jordas Precept Quest.
Field Bosses are rare boss-like enemies that hunt players in random locations after doing certain things against their Factions. Some field bosses only spawn after earning their respective Death Marks in the process, while others require players to be in a specific mission in order to spawn. Defeating these rare enemies may yield exquisitely rare resources, parts and blueprints.
- Main article: Corrupted Vor
Corrupted Vor is a corrupted Captain Vor and is the boss of the Orokin Void as an encounter in Tower IV missions. It is known that he was revived by his own Orokin Key during a normal assassination mission in Mercury and has since turned into the guardian of the Void. Vor will make his presence known via a taunting transmission, after which he will appear near players to engage them in battle.
- Main article: Zanuka Hunter
Zanuka Hunter, formerly dubbed as Harvester, is a gray-colored Zanuka proxy controlled by Alad V. During missions, it will attack one targeted Tenno until either the Tenno or Zanuka Hunter dies. It appears rarely, in a manner similar to the Stalker. Triggering a Zanuka Hunter attack requires a player to have a death-mark. A death-mark is acquired by supporting the Grineer in five consecutive Invasion missions.
- Main article: Juggernaut
The Juggernaut is a large quadruped Infested creature, armed with formidable ranged attacks and deadly close-quarters combat abilities, which combined with its heavy armor makes it an intimidating opponent.
- Main article: Lynx
The Lynx is a Field Boss that is encountered in certain Orokin Sabotage tiers that feature Corpus enemies, acting as the main miniboss from which the mission's Void Key drops. A (presumably stolen and re-programmed) Lynx can also appear as an active miniboss in one of the Grineer Spy mission tiles as a room centerpiece; the Lynx will activate if the player has been spotted/tripped the alarm before hacking the data vaults. It resembles a smaller Jackal with blue armor, and has the ability to deploy Osprey drones and Turrets to assist it in combat.
- Main article: Stalker
The Stalker is an ominous, vengeful figure that infrequently appears during missions, armed with powerful weapons and abilities to hunt down the Tenno.
The Stalker wears Warframe armor and is able to use ability powers from various other Warframes, in addition to Dispel, which is his signature ability. His arsenal is similar to that of the Tenno, utilizing a primary, secondary, and melee weapon. The Stalker's signature weapons are the bow, Dread, the scythe, Hate, and the throwing knives, Despair.
- Main article: The Grustrag Three
The Grustrag Three (commonly abbreviated as the G3) are a group of Assassins, founded by Councilor Vay Hek, who come after Tenno that have completed five consecutive Invasion missions against the Grineer.
- Main article: Ven'kra Tel
Ven'kra Tel is a special Grineer Field Boss unit encountered in Orokin Sabotage missions where Grineer are the dominant enemy, who is one of the two units who hold the Void Key necessary to close the Void Portal. She possesses a blue jet pack identical to that used by Hellions that grants her excellent mobility, and can use her Vulkar and other ranged special abilities to engage Tenno from afar.
Ven'kra Tel is always seen with her sister mini-boss, Sprag.
- Main article: Sprag
Sprag is a Grineer Field Boss encountered during Orokin Sabotage missions where Grineer are the dominant enemy. She is one of the two units who hold the Void Key necessary to close the Void Portal. She possesses a jet pack identical to that used by Hellions that grants her excellent mobility, and can use her Manticore Axe and other special melee abilities to engage Tenno in close combat. Sprag is always seen with her friend, Ven'kra Tel.
- All bosses and assassins have a rare chance to drop an Orokin Cell upon death. This chance is fully separate from the planet's resource drop rate.