Piercing Caliber makes this gun even more augmented versus Grineer because of their weakness to puncture damage, the Supra's strongest stat. The normal version, Piercing Hit, does not generally provide enough of a boost to puncture damage, and elementals would provide a larger boost in damage.
Shred or Metal Auger can help hit more enemies, somewhat balancing the high ammo consumption.
Due to the large magazine size of 300 bullets, Wildfire is a solid mod for this weapon as it can increase the overall damage of the weapon as well as alleviate some reload time issues.
Cancelling the reload animation on its third-quarter period counts as a reload, much like the Soma.
With the Entropy Burst equipped, It will increase the total status chance to 25%, which is very high for a heavy machine gun. Note that any mods that increase status chance (such as Malignant Force) only adds status based on the weapons original status chance, and not the new base status chance given by Entropy Burst. With all 4 dual stat mods and Split Chamber, the Supra Vandal can achieve a 58.4% status chance.
The Supra Vandal is the first Vandal weapon that can be fully recolored; most Vandal weapons can only have their energy colors changed.
Changing the energy color of the Supra Vandal will partially affect the energy color of the Supras wielded by Corpus Techs, making them periodically shoot bullets using the Supra Vandal's energy color.