With max Point Strike Synapse's crit chance can be increased up to 125%, ensuring critical hits while having 25% to proc Red Critical Hits, though a Rank 3 Point Strike will be sufficient to increase its crit chance to 100% if low on mod energy.
As mentioned above, using the Synapse in conjunction with Volt's Electric Shield worsens the Synapse's imperfect accuracy. When using Heavy Caliber, the accuracy is somewhat low at even medium range.
As of Update 11.0, the Synapse can no longer do constant red crits when used in conjunction with Volt's Electric Shield.
Crafting the Synapse used to require 11 Mutagen Masses and 3 Forma before being announced as a mistake, reducing it down to 5 and 2 respectively.
This makes Synapse the only weapon in the game to require more than 1 Forma to build.
The tendrils at the front end of the Synapse move, retracting and enclosing the muzzle upon holstering the rifle. This suggests the weapon is a living organism.
A Synapse is a nervous system structure that acts as a 'gate' between neurons, allowing electrical signals to be passed between nerve cells. Synapses help form the electrical pathways of the nervous system.
This weapon seems to be based on the Electric Crawler as it has similar lighting attacks.