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Weapon Slot Primary
Weapon Type Rifle
Trigger Type Continuous
Firing Rate 10.0 rounds/sec
Accuracy 12.5
Magazine Size 100 rounds/mag
Max Ammo 540 rounds
Reload Time 1.5s
Normal Attacks
Elemental Type
Elemental Dmg 12
Crit Chance 50.0%
Crit Damage 200%
Polarities None

CODEX Entry: SynapseCodexbw
Powered by a bio-chemical reaction, the infested Synapse rifle fries its targets with a steady stream of electricity.

The Synapse is an Infested bio-weapon that projects constant arcs of electricity. It is only available through Bio Lab Research in the Dojo.

The Synapse can be sold for Credits 32px ‍7,500.

Manufacturing Requirements
Credits 32px
Mutagen Mass2
Circuits 32px
Forma 32px
Time: 24 hr
Rush: Platinumicon 35
Market Price: N/A Blueprint Price: Credits 32px ‍50,000
Bio Lab Research Requirements
Credits 32px
Mutagen Sample Icon
Circuits 32px
Nano Spores 32px
Polymer Bundle 32px
Time: 72 hrs
Prereq: Embolist
Ghost x1   Shadow x3   Storm x10   Mountain x30   Moon x100



  • Tied with the Dread for the highest critical chance of any weapon.
  • Good base critical damage.
  • Instantly reaches its max range of 20m.
  • High magazine size.
  • High base damage.
  • Fast reload time.
  • Imperfect accuracy, unlike the Flux Rifle, making shots easier to hit without precise aiming
  • Good status effect chance.


  • Deals damage, which improves its utility against Robotic or Machinery-type foes but not others unless properly modded.
  • Requires a large amount of materials to craft, including 2 Forma.
  • Limited range (20m).
  • Imperfect accuracy is worsened through Electric Shield.
  • No polarity slots.
  • Poor ammo efficiency.

Weapon Loadouts

Main article: Category:Synapse Build

See the user build section for builds using this weapon.


  • It is a good weapon to use against robotics, especially combined with Volt's Electric Shield.
  • To have a "pure" element different from , you will have to add Stormbringer as a placeholder.
  • With max Point Strike Synapse's crit chance can be increased up to 125% so it's suggested to attach just a Rank 3 Point Strike which will increase Synapse's crit chance to 100% and save you 2 mod points.
    • Even though it is not recommended, there are instances where even at 100% crit chance, some numbers will show white regardless, even more so in Volt's Electric Shield (perhaps due to bonus added damage) and having a max Point Strike will eliminate these white numbers.
      • Statement above confirmed to be a bug which only happens on client side (when you are not host of game session).
  • As mentioned above, using the Synapse in conjunction with Volt's Electric Shield worsens the Synapse's imperfect accuracy. When using Heavy Caliber, the accuracy is somewhat low at even medium range.
    • As of Update 11, the Synapse can no longer do constant red crits when used in conjunction with Volt's Electric Shield.
  • Its high rate of fire, high status effect chance, and innate elemental nature allows it to be used very effectively with elemental modifications. By applying an elemental effect other than electricity you can reduce armor, reduce shields, or apply confusion with ease.


  • This item was added in Update 10.
  • Crafting the Synapse used to require 11 Mutagen Masses and 3 Forma before being announced as a mistake, reducing it down to 5 and 2 respectively.
  • The tendrils at the front end of the Synapse move, retracting and enclosing the muzzle upon holstering the rifle. This suggests the weapon is a living organism.
  • A Synapse is a nervous system structure that acts as a 'gate' between neurons, allowing electrical signals to be passed between nerve cells. Synapses help form the electrical pathways of the nervous system.
  • This weapon seems to be based on the Electric Crawler as it has similar lighting attacks.
  • The Synapse resembles the Shock Roach weapon from the game Half-Life: Opposing Force.


  • The colour cutomization options for the Synapse

Start a Discussion Discussions about Synapse

  • Phage or Synapse

    47 messages
    • Alright then, this might be offtopic, but how exactly a weapon with merely 200% crit damage and unnecessaribly big crit chance, 50% - better t...
    • wrote:20k what, burst? By popping an event mod and shotgun spazz? Dude... Seriously... 20.5K SUSTAINED DPS, No any event-exclus...
  • Synapse Nerf?

    3 messages
    • The damage was divided by ten, and the rate of fire was multiplied by ten. It's the same DPS but you burn ammo quicker, so yes, somewhat of a n...
    • From what I can gather from other continuous fire weapons that other users have explained, DE is now showing you the actual amount of damage ...
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