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Weapon Slot Primary
Weapon Type Rifle
Trigger Type Continuous
Noise Level 25.0m
Firing Rate 10.0 rounds/sec
Accuracy 12.5
Magazine Size 100 rounds/mag
Max Ammo 540 rounds
Reload Time 1.5s
Normal Attacks
Elemental Type Electricity b Electricity
Elemental Dmg 12.5
Crit Chance 50.0%
Crit Multiplier 2.0x
Polarities None
Introduced Update 10.0
Powered by a bio-chemical reaction, the infested Synapse rifle fries its targets with a steady stream of electricity.

The Synapse is an Infested bio-weapon that projects constant arcs of electricity. It is only available through Bio Lab Research in the Dojo.

The Synapse can be sold for Credits64‍ 7,500.

Manufacturing Requirements
Time: 24 hr
Rush: Platinum64 35
Market Price: N/A Blueprint Price: Credits64 ‍50,000
Bio Lab Research Requirements
Time: 72 hr
Prereq: Embolist
Ghost x1   Shadow x3   Storm x10   Mountain x35   Moon x100


This weapon deals primarily Electricity b Electricity damage.


  • Highest Critical Chance of all weapons, alongside the Dread and Amprex.
  • Instantly reaches its max range of 18m.
  • Large magazine size.
  • High base damage.
  • Fast reload time.
  • Imperfect accuracy, unlike the Flux Rifle, making shots easier to hit without precise aiming.
  • Specializes in Electricity b Electricity damage, making it effective against Robotic and Machinery-enemies. Electricity is a versatile damage type, combining for Magnetic b Magnetic, Corrosive b Corrosive and Radiation b Radiation.
  • Compared to the Amprex:
    • Faster reload speed.
    • Higher damage.
    • Lower ammo consumption.


  • Reliant on its high critical damage potential, which makes it ill-suited against Object-based health.
  • Damage cannot be increased with Slash b Slash, Impact b Impact or Puncture b Puncture mods.
  • When combining elements, Electricity b Electricity damage is added last.
  • Limited range (18m).
  • Imperfect accuracy is worsened through Electric Shield.
  • Poor ammo efficiency.

Weapon LoadoutsEdit

Main article: Category:Synapse Build

See the user build section for builds using this weapon.


  • It is a good weapon to use against robotics, especially combined with Volt's Electric Shield.
  • To have a "pure" element different from Electricity b Electricity, you will have to add Stormbringer and/or High Voltage as a placeholder.
  • With max Point Strike Synapse's crit chance can be increased up to 125%, ensuring critical hits while having 25% to proc Red Critical Hits, though a Rank 3 Point Strike will be sufficient to increase its crit chance to 100% if low on mod energy.
  • As mentioned above, using the Synapse in conjunction with Volt's Electric Shield worsens the Synapse's imperfect accuracy. When using Heavy Caliber, the accuracy is somewhat low at even medium range.
    • As of Update 11, the Synapse can no longer do constant red crits when used in conjunction with Volt's Electric Shield.
  • Its high rate of fire, high status effect chance, and innate elemental nature allows it to be used very effectively with elemental modifications. By applying an elemental effect other than electricity you can reduce armor, reduce shields, or apply confusion with ease.


  • This item was added in Update 10.
  • Crafting the Synapse used to require 11 Mutagen Masses and 3 Forma before being announced as a mistake, reducing it down to 5 and 2 respectively.
    • Synapse is the only weapon to require two Formas to be built.
  • The tendrils at the front end of the Synapse move, retracting and enclosing the muzzle upon holstering the rifle. This suggests the weapon is a living organism.
  • A Synapse is a nervous system structure that acts as a 'gate' between neurons, allowing electrical signals to be passed between nerve cells. Synapses help form the electrical pathways of the nervous system.
  • This weapon seems to be based on the Electric Crawler as it has similar lighting attacks.
  • The Synapse resembles the Shock Roach weapon from the game Half-Life: Opposing Force.


  • Synapse Colour Customization


See AlsoEdit

WeaponsDamageCompare AllCosmetics

Start a Discussion Discussions about Synapse

  • What is a good end game weapon?

    22 messages
    • May I humbly suggest Kohm, this thing is full noob mode if you can spare a few formas. Mod it with two RoF mods and a ammo mutation, rest ...
    • Soma - will last through a good chunk of T4 missions. High ROF, high crit damage, good accuracy. Very versatile. Used it a lot. Just keep in mi...
  • Synapse needing a buff?

    5 messages
    • Ok i just looked at the brakk for the first time and i can tell you nothing needs to be changed. when using the brakk you want to focus...
    • since amprex is more expensive and has a massive ammo burn while it deals lower dmg/

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